Klotho is produced naturally in the kidneys of humans and animals and has been shown to have a positive impact not only on kidney function but also diseases associated with aging.
Klotho is an anti-aging hormone detected in the brain, kidneys, urine, blood stream, and muscle. It is essential for a long, healthy life. Low Klotho levels have been associated with age-related disorders such as cardiovascular disease, diabetes, sarcopenia, and cognitive decline in both humans and laboratory animals.
Klotho shows great promise in the treatment of many types of cancer in animal studies. Klotho suppresses tumor growth, inhibits metastases, reduces resistance to chemo-therapy drugs and improves survival. Cancer is the leading cause of death in the US and new cancer cases are expected to grow 70% over the next 20 years; as most cancers are not curable.
The existing human and animal literature suggest that Klotho may be a promising biomarker for kidney disease and its symptoms. Future clinical studies should evaluate the safety and efficacy of Klotho therapy in CKD and AKI patients.
